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Showing 1–2 of 2 results
Advanced filters: Author: Mostafa Fraig Clear advanced filters

  • Chronic exposure to silica crystals can cause lung inflammation and cancer. Here, the authors show that mast cells and macrophages respond to silica crystals by producing leukotriene B4, which recruits neutrophils leading to inflammation, and that blocking this pathway attenuates cancer progression.

    • Shuchismita R. Satpathy
    • Venkatakrishna R. Jala
    • Bodduluri Haribabu
    Research
    Nature Communications
    Volume: 6, P: 1-12

  • In this study, the authors found that the transcriptional regulator myocyte enhancer binding factor 2 B (MEF2B) is an essential component of the BCL6 gene transcriptional complex and promotes diffuse large B-cell lymphoma (DLBCL) growth by inducing BCL6 expression. In addition to its regulatory role in DLBCL growth, MEF2B expression correlates positively with BCL6 and CD10 expression, and preferentially expressed in the germinal center B-cell-like DLBCL group.

    • Siraj M. El Jamal
    • Zakaria Grada
    • Mohamed Hassan
    Research
    Laboratory Investigation
    Volume: 99, P: 539-550