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Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade

Metal-ion-chelating phenylalanine nanostructures modulate ion influx and efflux in dendritic cells, activating them through the NLRP3 inflammasome and NF-κB pathway to remodel the immunosuppressive tumour microenvironment for PD-L1-based immunotherapy.

Mixiao Tan
Guoliang Cao
Hai Wang
Research26 Aug 2024
Nature Nanotechnology

Volume: 19, P: 1903-1913
Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity

The inflammasome is an essential component of inflammatory processes and the host response to infection. Here the authors show that inflammasome activation modulates MyD88-IRF7 type I IFN signalling and anti-malaria immunity.

Xiao Yu
Yang Du
Rong-Fu Wang
ResearchOpen Access23 Nov 2018
Nature Communications

Volume: 9, P: 1-12

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Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade

Inflammasome activation negatively regulates MyD88-IRF7 type I IFN signaling and anti-malaria immunity

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