The cytokines IL-17A and IL-17F bind via same receptor. Iwakura and colleagues demonstrate different functions for IL-17A and IL-17F in the gut, with the latter altering the production of antimicrobial peptides with consequent effects on the microbiota, the induction of Treg cells and immune-system homeostasis.
- Ce Tang
- Shigeru Kakuta
- Yoichiro Iwakura
