Loss-of-function mutations in EP300/KAT3B and CBP/KAT3A have been implicated in the pathogenesis of cancer. Here, the authors reveal that the EP300 protein has a role in mediating replication fork protection at sites of replication stalling and show that EP300-mutated cells recapitulate features of BRCA-deficient cancers.
- Angelica Barreto-Galvez
- Mrunmai Niljikar
- Advaitha Madireddy
