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Nature Aging (2)
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Advanced filters: Author: Muhamad Hartono Clear advanced filters

Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe

Hartono and colleagues develop an injectable albumin-based nanoprobe to enable urine detection of senescence burden. By exploiting the activity of MMP-7 as a context-specific biomarker of senescence, the probe enables real-time monitoring of treatment response in lung cancer and related pulmonary conditions.

Muhamad Hartono
Jianfeng Ge
Daniel Muñoz-Espín
ResearchOpen Access13 May 2026
Nature Aging

Volume: 6, P: 1158-1176
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated in clinical samples. Concomitantly blocking TGFβ signaling with chemotherapy reduces tumor burden and increases survival in mice.

Estela González-Gualda
Marika A. V. Reinius
Daniel Muñoz-Espín
ResearchOpen Access03 Feb 2026
Nature Aging

Volume: 6, P: 368-392
Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells

Muhamad Hartono
Andrew G. Baker
Ljiljana Fruk
ResearchOpen Access27 Nov 2024
Scientific Reports

Volume: 14, P: 1-14

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