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Showing 1–2 of 2 results
Advanced filters: Author: Muhammad F.M. Razif Clear advanced filters

  • PUF proteins bind RNA sequences through specific interactions between PUF repeats and adenine, guanine and uracil bases. A directed evolution approach has identified new PUF repeats that specifically bind cytosine, which enables the recognition of diverse RNA sequences by engineered PUF proteins.

    • Aleksandra Filipovska
    • Muhammad F M Razif
    • Oliver Rackham
    Research
    Nature Chemical Biology
    Volume: 7, P: 425-427

  • Pentatricopeptide repeat (PPR) proteins bind RNA and control diverse aspects of RNA metabolism in eukaryotic cells. Here, Coquille et al.present the crystal structures of several engineered PPR domains, elucidate their RNA binding mode and suggest paths to the design of modular, sequence-specific PPR domains.

    • Sandrine Coquille
    • Aleksandra Filipovska
    • Oliver Rackham
    Research
    Nature Communications
    Volume: 5, P: 1-9