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Showing 1–2 of 2 results
Advanced filters: Author: Murielle Chauvel Clear advanced filters

  • Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, Jaitly et al. identify several genes involved in chromosomal stability in Candida albicans, including a phylogenetically restricted gene encoding an essential cell-cycle progression factor.

    • Priya Jaitly
    • Mélanie Legrand
    • Kaustuv Sanyal
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogenCandida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs.

    • Flore Mietton
    • Elena Ferri
    • Carlo Petosa
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15