Nature Search

Differential stimulation of capped mRNA translation in vitro by cap binding protein

N. Sonenberg
H. Trachsel
A. J. Shatkin
Research29 May 1980
Nature

Volume: 285, P: 331-333
mTOR, translation initiation and cancer

Y Mamane
E Petroulakis
N Sonenberg
Reviews16 Oct 2006
Oncogene

Volume: 25, P: 6416-6422
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Here, Tain et al. describe the genetic interaction between 4E-BP, an inhibitor of translation, with Parkinson's disease–associated park and Pink1 in Drosophila, where the manipulation of 4E-BP reduced the pathologic phenotypes, including degeneration of dopaminergic neurons, in park and Pink1 mutant flies.

Luke S Tain
Heather Mortiboys
Alexander J Whitworth
Research16 Aug 2009
Nature Neuroscience

Volume: 12, P: 1129-1135
Sequence of reovirus haemagglutinin predicts a coiled-coil structure

Rhonda Bassel-Duby
Anula Jayasuriya
Bernard N. Fields
Research30 May 1985
Nature

Volume: 315, P: 421-423
mTOR signaling: implications for cancer and anticancer therapy

E Petroulakis
Y Mamane
N Sonenberg
ReviewsOpen Access13 Dec 2005
British Journal of Cancer

Volume: 94, P: 195-199
VSV-tumor selective replication and protein translation

Glen N Barber
Reviews21 Nov 2005
Oncogene

Volume: 24, P: 7710-7719
Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

Paul R. Clapham
Jonathan N. Weber
Robin A. Weiss
Research26 Jan 1989
Nature

Volume: 337, P: 368-370
Direct interaction of human TFIID with the HIV-1 transactivator Tat

Fatah Kashanchi
Graziella Piras
John N. Brady
Research20 Jan 1994
Nature

Volume: 367, P: 295-299
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

Todd Waldman
Christoph Lengauer
Bert Vogelstein
Research20 Jun 1996
Nature

Volume: 381, P: 713-716
Correction: A canine distemper virus epidemic in Serengeti lions (Panthera leo)

Melody E. Roelke-Parker
Linda Munson
Max J. G. Appel
Amendments and Corrections09 May 1996
Nature

Volume: 381, P: 172
Translon: a single term for translated regions

Michał I. Świrski
Jack A. S. Tierney
Pavel V. Baranov
Correspondence01 Sept 2025
Nature Methods

Volume: 22, P: 2002-2006
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.

John Maringa Githaka
Namita Tripathi
Ing Swie Goping
ResearchOpen Access19 May 2021
Nature Communications

Volume: 12, P: 1-18
Exaggerated translation causes synaptic and behavioural aberrations associated with autism

Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation inhibitor 4EGI-1.

Emanuela Santini
Thu N. Huynh
Eric Klann
Research23 Dec 2012
Nature

Volume: 493, P: 411-415
Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

Tatyana V. Pestova
Sergei I. Borukhov
Christopher U. T. Hellen
Research27 Aug 1998
Nature

Volume: 394, P: 854-859
Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2

Viruses have found mechanisms to translate their RNAs in the face of antiviral responses. Data now indicate that the hepatitis C virus internal ribosome entry site can use eIF5B to initiate translation in a bacterial-like mode when eIF2 is inactivated under stress.

Ilya M Terenin
Sergey E Dmitriev
Ivan N Shatsky
Research06 Jul 2008
Nature Structural & Molecular Biology

Volume: 15, P: 836-841
Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA

Daiki Matsuda
Nao Hosoda
Lynne E Maquat
Research16 Sept 2007
Nature Structural & Molecular Biology

Volume: 14, P: 974-979
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway

M Marzec
M Kasprzycka
M A Wasik
Research12 Mar 2007
Oncogene

Volume: 26, P: 5606-5614
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Deregulation of mTORC1 pathway has been associated with several human diseases including diabetes, neurodegeneration and cancer. Here Blandino-Rosanoet al. show that mTORC1 signalling controls insulin secretion and β-cell maintenance by regulation of β-cell proliferation, apoptosis and autophagy and insulin processing.

Manuel Blandino-Rosano
Rebecca Barbaresso
Ernesto Bernal-Mizrachi
ResearchOpen Access12 Jul 2017
Nature Communications

Volume: 8, P: 1-15
Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

L J Coleman
M B Peter
T A Hughes
ResearchOpen Access14 Apr 2009
British Journal of Cancer

Volume: 100, P: 1393-1399
Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein

D. N. Lyabin
L. P. Ovchinnikov
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

CPEB4 binds the mRNA of genes known to be associated with autism and shows an isoform imbalance in individuals with autism, and an equivalent imbalance in mice induces an autism-like phenotype.

Alberto Parras
Héctor Anta
José J. Lucas
Research15 Aug 2018
Nature

Volume: 560, P: 441-446
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

MicroRNAs mediate post-translational regulation of gene expression in various organisms. Although it is clear that the specificity of their action is achieved by base-pair complementarity, the precise mechanism by which they repress translation has been controversial. Clear answers are only beginning to emerge.

Witold Filipowicz
Suvendra N. Bhattacharyya
Nahum Sonenberg
Reviews01 Feb 2008
Nature Reviews Genetics

Volume: 9, P: 102-114
Translational control in stress and apoptosis

Martin Holcik
Nahum Sonenberg
Reviews01 Apr 2005
Nature Reviews Molecular Cell Biology

Volume: 6, P: 318-327
Impaired protein translation in Drosophila models for Charcot–Marie–Tooth neuropathy caused by mutant tRNA synthetases

Charcot–Marie–Tooth (CMT) neuropathy is associated with dominant mutations in five tRNA synthetase genes. Niehues et al. use BONCAT and FUNCAT to monitor proteome dynamics in a DrosophilaCMT model, and reveal that these mutations result in translational slowdown.

Sven Niehues
Julia Bussmann
Erik Storkebaum
ResearchOpen Access03 Jul 2015
Nature Communications

Volume: 6, P: 1-13
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)

Here, the authors discuss dual-reporter systems and confounding variables that may lead to misinterpretation of results. They propose guidelines for robust design, physiological interpretation and accurate reporting when using dual reporters.

Gary Loughran
Dmitry E. Andreev
Pavel V. Baranov
Reviews03 Mar 2025
Nature Structural & Molecular Biology

Volume: 32, P: 418-430
Identification of secondary structure in the 5′-untranslated region of the human adrenomedullin mRNA with implications for the regulation of mRNA translation

F Brenet
N Dussault
L H Ouafik
Research22 May 2006
Oncogene

Volume: 25, P: 6510-6519
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeostasis but to be necessary for the triggering of tumorigenesis by APC mutations, suggesting that it could be a good target for the prevention of colorectal cancer in high-risk patients.

William J. Faller
Thomas J. Jackson
Owen J. Sansom
Research05 Nov 2014
Nature

Volume: 517, P: 497-500
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

X Wan
B Harkavy
L J Helman
Research25 Sept 2006
Oncogene

Volume: 26, P: 1932-1940
Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours

Y Nakagawa
H Morikawa
Y Akao
ResearchOpen Access23 Apr 1999
British Journal of Cancer

Volume: 80, P: 914-917
Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

M N Corradetti
K-L Guan
Reviews16 Oct 2006
Oncogene

Volume: 25, P: 6347-6360
Eukaryotic initiation factor 6 selectively regulates Wnt signaling and β-catenin protein synthesis

Y Ji
S Shah
S Byers
Research30 Jul 2007
Oncogene

Volume: 27, P: 755-762
AKT signaling in normal and malignant cells

Joseph R Testa
Philip N Tsichlis
Reviews14 Nov 2005
Oncogene

Volume: 24, P: 7391-7393
The Genetic Engineering of Two Commercial Potato Cultivars for Resistance to Potato Virus X

André Hoekema
Marianne J. Huisman
Ben J. C. Cornelissen
Research01 Mar 1989
Bio/Technology

Volume: 7, P: 273-278
Regulation of protein translation and c-Jun expression by prostate tumor overexpressed 1

N Marqués
M Sesé
R Paciucci
Research04 Mar 2013
Oncogene

Volume: 33, P: 1124-1134
Oncogenic Ras inhibits IRF1 to promote viral oncolysis

Y Komatsu
S L Christian
K Hirasawa
Research27 Oct 2014
Oncogene

Volume: 34, P: 3985-3993
mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation

A Alayev
R S Salamon
M K Holz
Research02 Nov 2015
Oncogene

Volume: 35, P: 3535-3543
DAPK2 is a novel regulator of mTORC1 activity and autophagy

Y Ber
R Shiloh
A Kimchi
ResearchOpen Access31 Oct 2014
Cell Death & Differentiation

Volume: 22, P: 465-475
AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B

A G M van Gorp
K E van der Vos
P J Coffer
Research06 Oct 2008
Oncogene

Volume: 28, P: 95-106
An oncogenic role of eIF3e/INT6 in human breast cancer

M Grzmil
T Rzymski
C J Norbury
Research10 May 2010
Oncogene

Volume: 29, P: 4080-4089
Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

E W Duiker
A Meijer
S de Jong
ResearchOpen Access12 Apr 2011
British Journal of Cancer

Volume: 104, P: 1278-1287
Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis

W E Marissen
A Gradi
R E Lloyd
Research13 Dec 2000
Cell Death & Differentiation

Volume: 7, P: 1234-1243
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt

R B Robey
N Hay
Reviews07 Aug 2006
Oncogene

Volume: 25, P: 4683-4696
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

N Robichaud
S V del Rincon
N Sonenberg
Research09 Jun 2014
Oncogene

Volume: 34, P: 2032-2042
The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner

Y K Im
R La Selva
J Ursini-Siegel
Research19 May 2014
Oncogene

Volume: 34, P: 1729-1735
Akt phosphorylation of La regulates specific mRNA translation in glial progenitors

F Brenet
N D Socci
E C Holland
Research06 Oct 2008
Oncogene

Volume: 28, P: 128-139
LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression

M Mura
T G Hopkins
S P Blagden
ResearchOpen Access22 Dec 2014
Oncogene

Volume: 34, P: 5025-5036

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