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Showing 1–2 of 2 results
Advanced filters: Author: N. N. Parayath Clear advanced filters

  • Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide therapeutic effects in mouse models of cancer or viral infection.

    • N. N. Parayath
    • S. B. Stephan
    • M. T. Stephan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • The previous efforts to reprogramme tumour-associated macrophages (TAMs) to M1 phenotype have caused undesired side-effects. Here, the authors report targeted nanocarriers for delivering mRNA encoding M1-polarizing transcription factors to TAMs and show their efficacy in multiple mouse tumour models.

    • F. Zhang
    • N. N. Parayath
    • M. T. Stephan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16