Precision oncology for hepatocellular carcinoma (HCC) remains challenging due to the high diversity of HCC at the clinical and molecular levels. Here, the authors employ an integrative multi-omics approach to identify and characterize nine molecular subtypes and explore their biological and clinical significance via p53/WNT scoring, immune infiltration analyses, and in vivo models.
- Long Pan
- Théo Z. Hirsch
- Jessica Zucman-Rossi
