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Showing 1–4 of 4 results
Advanced filters: Author: Nadia Leloup Clear advanced filters

  • Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH and further propose a model for low pH-induced ligand release by endocytosis receptors.

    • Nadia Leloup
    • Philip Lössl
    • Bert J. C. Janssen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Using directed evolution and structure-guided design, human synthetic antibodies selective to HER2 point mutants were developed. The use of the antibodies as T cell engagers killed HER2-mutant cancer cells while sparing HER2-wild-type normal cells.

    • Injin Bang
    • Takamitsu Hattori
    • Shohei Koide
    Research
    Nature Chemical Biology
    Volume: 21, P: 706-715

  • The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in complex with Nerve Growth Factor, which provides insights into SorCS2 ligand binding and signaling.

    • Nadia Leloup
    • Lucas M. P. Chataigner
    • Bert J. C. Janssen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10