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Advanced filters: Author: Nadia Mekrane Clear advanced filters

  • HCN4 channels control cardiac pacing. Here, the authors isolated a nanobody (NB5) that binds HCN4 extracellularly in an ortholog- and isoform-specific manner and promotes its activation in sinoatrial node myocytes, leading to an increase in pacemaker rhythm.

    • Atiyeh Sadat Sharifzadeh
    • Roberta Castelli
    • Anna Moroni
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12