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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

Roan et al. use Olink and single‐cell RNA sequencing (scRNA-seq) to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months postinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Kailin Yin
Michael J. Peluso
Nadia R. Roan
ResearchOpen Access11 Jan 2024
Nature Immunology

Volume: 25, P: 218-225
Conquering sexually transmitted diseases

In this Perspective article, Michael Starnbach and Nadia Roan discuss the public-health and social impact of sexually transmitted diseases, raising several questions that need to be addressed before these diseases can be conquered.

Michael N. Starnbach
Nadia R. Roan
Comments & Opinion29 Feb 2008
Nature Reviews Immunology

Volume: 8, P: 313-317
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Infection with Omicron after vaccination produces cross-neutralizing antibodies to other variants of concern, whereas this induces a limited response to non-Omicron variants in unvaccinated individuals.

Rahul K. Suryawanshi
Irene P. Chen
Melanie Ott
ResearchOpen Access18 May 2022
Nature

Volume: 607, P: 351-355
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen

Semen-derived peptides can form amyloid fibrils that boost HIV infection in vitro, but the existence of such fibrils in semen remained to be demonstrated. Here, the authors show that human semen contains amyloid fibrils, which can bind HIV particles and increase their infectiveness.

Shariq M. Usmani
Onofrio Zirafi
Jan Münch
Research01 Apr 2014
Nature Communications

Volume: 5, P: 1-8
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses

Short peptides derived from the HIV-1 glycoprotein form nanofibrils that can be used to improve viral gene delivery and concentrate viruses without the need for ultracentrifugation.

Maral Yolamanova
Christoph Meier
Jan Münch
Research20 Jan 2013
Nature Nanotechnology

Volume: 8, P: 130-136
Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection

In this study, Giron et al. find that people living with chronic HIV experience accelerated aging-associated alterations in antibody glycans. These alterations, attributed to senescence enzymes, predict comorbidities and reduce the antiviral function of antibodies.

Leila B. Giron
Qin Liu
Mohamed Abdel-Mohsen
ResearchOpen Access10 Apr 2024
Nature Communications

Volume: 15, P: 1-23
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection

Johanne H. Egedal
Guorui Xie
Nadia R. Roan
ResearchOpen Access11 May 2021
Mucosal Immunology

Volume: 14, P: 1203-1213
Semen inhibits Zika virus infection of cells and tissues from the anogenital region

Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.

Janis A. Müller
Mirja Harms
Jan Münch
ResearchOpen Access07 Jun 2018
Nature Communications

Volume: 9, P: 1-14
Silencing the transcriptionally active HIV reservoir to improve treatment outcomes

Persistence of the transcriptionally active HIV reservoir has important implications for people living with HIV, including chronic immune activation and inflammation. Supplementing antiretroviral therapy with transcriptional inhibitors could overcome this by silencing the transcriptionally active HIV reservoir.

Julia Prigann
Rubens Tavora
Melanie Ott
Comments & Opinion17 Sept 2024
Nature Microbiology

Volume: 9, P: 2470-2472

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