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Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization

A tunable granular biomaterial matrix is developed to support long-term bioprinting. Stress relaxation at high strains and long timescales is shown to be important for tissue self-organization in intestinal organoids.

Austin J. Graham
Michelle W. L. Khoo
Zev J. Gartner
ResearchOpen Access10 Mar 2026
Nature Materials

P: 1-13
Desensitization of human breast progenitors by a transient exposure to pregnancy levels of estrogen

Lone Rønnov-Jessen
Jiyoung Kim
Ole William Petersen
ResearchOpen Access26 Aug 2021
Scientific Reports

Volume: 11, P: 1-7
Ductal keratin 15⁺ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

Katharina Theresa Kohler
Nadine Goldhammer
Jiyoung Kim
ResearchOpen Access12 Jul 2022
npj Breast Cancer

Volume: 8, P: 1-12
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Deuterium/hydrogen exchange shows that conformational flexibility of the hybrid transmembrane domains (TMD) of amyloid precursor proteins plays a role in TMD cleavability by γ-secretase in vitro and in cellulo.

Nadine T. Werner
Philipp Högel
Dieter Langosch
ResearchOpen Access15 Feb 2023
Communications Biology

Volume: 6, P: 1-13
Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation

Breast myoepithelial cells are characterised using single cell sequencing, where they are distinguished by CD200 expression. Distinct properties of CD200-low and CD200-high are found, which suggest that CD200-low cells are multipotent, whereas CD200-high cells are bipotent.

Nadine Goldhammer
Jiyoung Kim
Ole William Petersen
ResearchOpen Access10 Mar 2022
Communications Biology

Volume: 5, P: 1-13

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Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization

Desensitization of human breast progenitors by a transient exposure to pregnancy levels of estrogen

Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation

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Ductal keratin 15⁺ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature