Amoeboid motility is driven by actomyosin-based contraction and exploits differences in the mechanical properties of the cortical cytoskeleton. Here the authors discover that mDia1-like formin A is responsible for generating a subset of actin filaments at the rear of Dictyosteliumthat suppresses lateral protrusions and blebbing during 2D-confined migration.
- Nagendran Ramalingam
- Christof Franke
- Jan Faix
