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Showing 1–5 of 5 results
Advanced filters: Author: Nail Fatkhutdinov Clear advanced filters

  • Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inflammatory senescence-associated secretory phenotype and to enable the response to immune checkpoint blockade.

    • Bo Zhao
    • Pingyu Liu
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Nacarelli et al. show that the nicotinamide-phosphoribosyltransferase-regulated NAD+ biogenesis pathway promotes the proinflammatory senescence-associated secretory phenotype by enhancing glycolysis and mitochondrial respiration during senescence.

    • Timothy Nacarelli
    • Lena Lau
    • Rugang Zhang
    Research
    Nature Cell Biology
    Volume: 21, P: 397-407

  • Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in copy number.

    • Bo Zhao
    • Jianhuang Lin
    • Rugang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13