Nature Search

FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours

The majority of ovarian granulosa tumours harbour the C134W mutation in FOXL2 but the mechanism of tumorigenesis is largely unknown. Here, Kim et al. show that mutant FOXL2 is hyperphosphorylated by GSK3β, which targets the protein for degradation, and find that GSK3β inhibition represses the growth of ovarian granulosa cells.

Jae-Hong Kim
Yong-Hak Kim
Jeehyeon Bae
Research03 Jan 2014
Nature Communications

Volume: 5, P: 1-13
Crystal structure of Fis1 and Bap31 provides information on protein-protein interactions at mitochondria-associated ER membranes

Structural analysis of Fis1-Bap31 interaction reveals a weak but unique interface between 2 proteins, illuminating how MAM-associated proteins mediate organelle tethering and signaling at ER-mitochondria contact sites.

Minh Duc Nguyen
Yonghyeok Kim
Byung Il Lee
ResearchOpen Access06 Aug 2025
Communications Biology

Volume: 8, P: 1-13
Supramolecular assembly and acid resistance of Helicobacter pylori urease

Nam-Chul Ha
Sang-Taek Oh
Byung-Ha Oh
Research01 Jun 2001
Nature Structural Biology

Volume: 8, P: 505-509
Crystal structures of a novel, thermostable phytase in partially and fully calcium-loaded states

Nam-Chul Ha
Byung-Chul Oh
Byung-Ha Oh
Research01 Feb 2000
Nature Structural Biology

Volume: 7, P: 147-153
Structural basis for lamin assembly at the molecular level

Lamins are intermediate filaments and the major component of the nuclear lamina. Here the authors determine the crystal structure of a construct comprising the N-terminal half of human lamin A/C and use their structure and cross-linking and biochemical experiments to discuss lamin assembly.

Jinsook Ahn
Inseong Jo
Nam-Chul Ha
ResearchOpen Access21 Aug 2019
Nature Communications

Volume: 10, P: 1-12
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

An unbiased genetic screen in Drosophila expressing G₄C₂-repeat-containing transcripts (repeats that in human cause pathogenesis in C9orf72-related neurological disease) finds genes that encode components of the nuclear pore and nucleocytoplasmic transport machinery, and reveals that G₄C₂ expanded-repeat-induced alterations in nucleocytoplasmic transport contribute to C9orf72 pathology and neurodegeneration.

Brian D. Freibaum
Yubing Lu
J. Paul Taylor
Research26 Aug 2015
Nature

Volume: 525, P: 129-133
Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

Ji-Yun Chung
Hee Ra Park
Bum-Joon Park
Research22 Apr 2013
Laboratory Investigation

Volume: 93, P: 663-676
Staphylococcus equorum plasmid pKS1030-3 encodes auxiliary biofilm formation and trans-acting gene mobilization systems

Sojeong Heo
Seung-Eun Oh
Do-Won Jeong
ResearchOpen Access10 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation

Characterization of the structure of an overoxidation-mimicking double mutant of superoxide dismutase SOD1 shows the production of more cytotoxic filaments seen in amyotrophic lateral sclerosis (ALS) neurons.

Yeongjin Baek
Tae-Gyun Woo
Nam-Chul Ha
ResearchOpen Access12 Oct 2022
Communications Biology

Volume: 5, P: 1-13
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

Kang, Park and colleagues develop and demonstrate the effects of a new drug candidate for treatment of Hutchinson-Gilford progeria syndrome pathologies. Progerinin extends the life span of mice used to model this disease and induces histological and physiological improvements.

So-mi Kang
Min-Ho Yoon
Bum-Joon Park
ResearchOpen Access04 Jan 2021
Communications Biology

Volume: 4, P: 1-11
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

So-mi Kang
Min-Ho Yoon
Bum-Joon Park
ResearchOpen Access27 Apr 2021
Scientific Reports

Volume: 11, P: 1-14
Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation

Increased hydrophobicity identified by the crystal structure presented in this work suggests a mechanism by which the S143F form of lamin A/C leads to progeria, a rapid aging syndrome. The authors observed aberrant molecular interactions that appear to lead to the nuclear deformation seen in other progeroid syndromes.

Jinsook Ahn
Soyeon Jeong
Nam-Chul Ha
ResearchOpen Access25 Mar 2022
Communications Biology

Volume: 5, P: 1-8
Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model

With ELISA-based screening, Woo et al. identify a new small molecule, PRG-A01, which can block the misfolding/aggregation of SOD1 or TDP-43 in a human neuroblastoma cell line. Its use in a mouse model of ALS results in improvement of muscle strength, motor neuron viability and mobility, highlighting its therapeutic potential in ALS.

Tae-Gyun Woo
Min-Ho Yoon
Bum-Joon Park
ResearchOpen Access15 Dec 2021
Communications Biology

Volume: 4, P: 1-12
The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli

Minho Lee
Minju Joo
Kangseok Lee
ResearchOpen Access21 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species

Zee-Won Lee
Byoung Sik Kim
Sang Ho Choi
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

Min-Ho Yoon
So-mi Kang
Bum-Joon Park
ResearchOpen Access06 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-18
Author Correction: Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

So‑mi Kang
Min‑Ho Yoon
Bum‑Joon Park
Amendments and CorrectionsOpen Access01 Sept 2021
Scientific Reports

Volume: 11, P: 1-3
Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

So-mi Kang
Min-Ho Yoon
Bum-Joon Park
Amendments and CorrectionsOpen Access02 Mar 2021
Communications Biology

Volume: 4, P: 1
Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation

Jungsug Gwak
Sun Gwan Hwang
Sangtaek Oh
Research09 Aug 2011
Cell Research

Volume: 22, P: 237-247

Search

FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours

Crystal structure of Fis1 and Bap31 provides information on protein-protein interactions at mitochondria-associated ER membranes

Supramolecular assembly and acid resistance of Helicobacter pylori urease

Crystal structures of a novel, thermostable phytase in partially and fully calcium-loaded states

Structural basis for lamin assembly at the molecular level

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

Staphylococcus equorum plasmid pKS1030-3 encodes auxiliary biofilm formation and trans-acting gene mobilization systems

Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation

Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation

Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model

The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli

Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species

p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

Author Correction: Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome

Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation

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