Kainate receptor (KAR) desensitization is structurally and functionally distinct among iGluRs. Here, authors used cryo-EM and electrophysiology to reveal that ligand-binding domain rotations are essential for full channel closure and stabilization of the desensitized state of KARs.
- Changping Zhou
- Guadalupe Segura-Covarrubias
- Nami Tajima
