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Showing 1–4 of 4 results
Advanced filters: Author: Namit Chaudhary Clear advanced filters

  • The emergence of lipid nanoparticles as nucleic acid delivery vehicles has revolutionized medicine, with polyethylene glycol (PEG)-lipids playing a crucial role in particle formation and in vivo fate. However, PEG has been linked to immune responses that can provoke side effects and may prevent repeat dosing, and so PEG alternatives are now being developed. Here we argue that, rather than concentrating on PEG replacement, the field should prioritize designing around pre-existing immune memory.

    • Namit Chaudhary
    • Kathryn A. Whitehead
    Comments & Opinion
    Nature Materials
    Volume: 24, P: 1666-1669

  • The COVID-19 pandemic has established mRNA vaccines as a rapid, effective and safe approach for the protection of individuals from infectious disease. Here, Whitehead and colleagues review the principles of mRNA vaccine design, synthesis and delivery, assessing recent progress and key issues in the development of mRNA vaccines for a range of infectious diseases.

    • Namit Chaudhary
    • Drew Weissman
    • Kathryn A. Whitehead
    Reviews
    Nature Reviews Drug Discovery
    Volume: 20, P: 817-838