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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

Zsuzsanna Izsvák and colleagues report the generation of a hyperactive version of the Sleeping Beauty transposase that supports efficient and stable gene transfer into human CD34⁺ cells enriched for hematopoietic stem or progenitor cells.

Lajos Mátés
Marinee K L Chuah
Zsuzsanna Izsvák
Research03 May 2009
Nature Genetics

Volume: 41, P: 753-761
Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy

Alanna J Church
Monica L Calicchio
Marian H Harris
Research03 Nov 2017
Modern Pathology

Volume: 31, P: 463-473

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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy

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