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Showing 1–2 of 2 results
Advanced filters: Author: Nancy D. Ebelt Clear advanced filters

  • The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult to target pharmacologically. Here, the authors identify a small molecule inhibitor that binds covalently to the D-recruitment site of ERK and induces cell death and reduces tumour growth in mice.

    • Tamer S. Kaoud
    • William H. Johnson
    • Kevin N. Dalby
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.

    • Flavia Chiuppesi
    • Marcela d’Alincourt Salazar
    • Felix Wussow
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16