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Showing 1–2 of 2 results
Advanced filters: Author: Nandakumar Rajasekaran Clear advanced filters

  • Mechanical unfolding of huntingtin mRNA with optical tweezers reveals how CAG repeat expansion triggers base pair reshuffling and favors RNA aggregation that is a hallmark of Huntington’s Disease.

    • Brett M. O’Brien
    • Roumita Moulick
    • Sarah A. Woodson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • In vivo experiments and optical tweezers force-spectroscopy measurements assessing the co-translational folding of the G-domain from bacterial elongation factor G reveal a sequential folding pathway initiating from the C-terminus. These results suggest that protein folding and synthesis proceed in opposite directions.

    • Xiuqi Chen
    • Nandakumar Rajasekaran
    • Christian M. Kaiser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9