Treatment with exogenous leptin has been reported to improve hyperglycemia in mouse models of type 1 diabetes through lowering of glucagon signaling. Jerry Shulman and his colleagues now report that the more primary beneficial effect of leptin on hyperglycemia is by reducing the activity of the hypothalamic-pituitary-adrenal axis. These results give further credence to the possible use of leptin therapy for this form of diabetes.
- Rachel J Perry
- Xian-Man Zhang
- Gerald I Shulman
