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Showing 1–5 of 5 results
Advanced filters: Author: Naomi R. Genuth Clear advanced filters

  • This Review discusses the effects of three age-associated stressors—loss of proteostasis, oxidative damage and dysregulated nutrient sensing—on global protein synthesis and highlights how altered translation is used by the cell as a stress sensor.

    • Naomi R. Genuth
    • Andrew Dillin
    Reviews
    Nature Cell Biology
    Volume: 27, P: 1609-1621

  • Specialized activities of ribosomal components that regulate the expression of specific genes is an emerging field of research. A new study identifies alternative splicing of a ribosomal protein between the peripheral and core regions of glioblastoma tumours to produce isoforms with distinct functions.

    • Naomi R. Genuth
    • Maria Barna
    News & Views
    Nature Cell Biology
    Volume: 24, P: 1451-1453

  • A nucleotide repeat expansion in the C9orf72 gene is the most common cause of amyotrophic lateral sclerosis. The mutation causes production of aberrant proteins by an enigmatic form of translation. Yamada et al. identify that RPS25 is required for this form of translation.

    • Shizuka B. Yamada
    • Tania F. Gendron
    • Aaron D. Gitler
    Research
    Nature Neuroscience
    Volume: 22, P: 1383-1388

  • Variation in the composition of translation complexes may serve as a means to regulate gene expression. How translation of select transcripts is achieved by specialized components and the role of this form of dynamic control of gene expression in disease are reviewed.

    • Naomi R. Genuth
    • Maria Barna
    Reviews
    Nature Reviews Genetics
    Volume: 19, P: 431-452