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Showing 1–4 of 4 results
Advanced filters: Author: Narayan Ramamurthy Clear advanced filters

  • Hepatitis C virus (HCV) infection blunts induction of hepcidin expression by bone morphogenetic protein 6 (BMP6), probably via TNF-mediated downregulation of the BMP co-receptor HJV, while BMP6 regulates a gene repertoire reminiscent of type I IFN signalling. BMP6 and related activin proteins potently block replication of HCV, hepatitis B virus and Zika virus independently of IFN.

    • Lucy A. Eddowes
    • Kinda Al-Hourani
    • Hal Drakesmith
    Research
    Nature Microbiology
    Volume: 4, P: 339-351

  • Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT or T cell proliferation assay is used has a major effect on this discriminatory ability.

    • Ane Ogbe
    • Barbara Kronsteiner
    • Susanna Dunachie
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B.

    • Bonnie van Wilgenburg
    • Iris Scherwitzl
    • Paul Klenerman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11