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Showing 1–2 of 2 results
Advanced filters: Author: Narendra K. Chunduri Clear advanced filters

  • The mechanisms that allow cancer cells to survive with monosomies are poorly understood. Here the authors analyse p53-deficient monosomic cell lines using transcriptomics and proteomics, and find that impaired ribosome biogenesis and p53 downregulation are associated with sustained monosomies.

    • Narendra Kumar Chunduri
    • Paul Menges
    • Zuzana Storchova
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Studying trisomic cell lines derived from RPE1 and HCT116 cells, Krivega et al find that autophagy is induced independently of mTORC1 in these cells. Rather, they observe that nuclear accumulation of TFEB and IRF3 and activation of the inflammatory response and autophagy in trisomic cells is dependent on the cGAS-STING pathway.

    • Maria Krivega
    • Clara M. Stiefel
    • Zuzana Storchová
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16