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Showing 1–13 of 13 results
Advanced filters: Author: Naruhiko Adachi Clear advanced filters

  • CphA1 catalyzes the synthesis of cyanophycin polypeptide consisting of equimolar amounts of aspartate and arginine as a fixed nitrogen reservoir in cyanobacteria. Here, the authors solve the cryo-EM structures of CphA1, revealing the aspartate binding mode and protein dynamics required for cyanophycin elongation.

    • Takuya Miyakawa
    • Jian Yang
    • Masaru Tanokura
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • FoF1-ATP synthase converts proton motive force into ATP, with the H+/ATP ratio typically ranging from 2.7 to 5. Here, the authors engineered this enzyme to form multiple peripheral stalks, achieving an H+/ATP ratio of 5.8—the highest yet reported.

    • Hiroshi Ueno
    • Kiyoto Yasuda
    • Hiroyuki Noji
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Transfer RNA maturation requires removal of extra sequences for proper function. Here, authors reveal how HARP, a protein-based enzyme, forms dodecamers that recognize specific tRNA features and process both 5′-leader and 3′-trailer sequences, demonstrating functional evolution.

    • Takamasa Teramoto
    • Takeshi Koyasu
    • Yoshimitsu Kakuta
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The authors identify V-161, a compound that inhibits enterococcal Na+-V-ATPase and reduces VRE colonization in mice. The high-resolution structure of V-161 reveals its action on the Na+ transport pathway, offering new therapeutic insights.

    • Kano Suzuki
    • Yoshiyuki Goto
    • Takeshi Murata
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 450-458

  • Recently, the pyridoxal-5′-phosphate-dependent enzyme SbzP was reported to catalyse a [3+2]-annulation reaction yielding β-NAD-derived antibiotics. Now, cryo-electron microscopy structures of a stable homologue and computational simulations provide structural and mechanistic insights into this enzymatic reaction.

    • Takayoshi Awakawa
    • Takahiro Mori
    • Ikuro Abe
    ResearchOpen Access
    Nature Catalysis
    Volume: 7, P: 1099-1108

  • A light-harvesting chlorophyll-binding protein complex from an Antarctic green alga called Prasiola crispa can excite photosystem II with low energy far-red light. Here, through Cryo-EM analysis, the authors reveal its ring-shaped structure with 11-fold symmetry at 3.13 Å resolution.

    • Makiko Kosugi
    • Masato Kawasaki
    • Toshiya Senda
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • DNMT1 is an essential for maintaining genomic DNA methylation. Here, we report the cryo-EM structure of DNMT1 bound to ubiquitinated H3 and hemimethylated DNA, revealing structural insight into the activation mechanism of DNMT1.

    • Amika Kikuchi
    • Hiroki Onoda
    • Kyohei Arita
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Chimeric triterpene synthases are identified that catalyse non-squalene-dependent triterpene biosynthesis.

    • Hui Tao
    • Lukas Lauterbach
    • Tiangang Liu
    ResearchOpen Access
    Nature
    Volume: 606, P: 414-419

  • In C-glycosides the sugar moiety is linked through a carbon-carbon bond to the non-sugar moiety, which can be cleaved by intestinal microbes. Here, the authors use bioinformatics analysis to identify C-glycoside deglycosidase enzymes in intestinal and soil bacteria, biochemically characterise them and determine their structures and probe catalytic important residues in mutagenesis experiments.

    • Takahiro Mori
    • Takuto Kumano
    • Michihiko Kobayashi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • A series of Toll-like receptor 7 (TLR7)-specific antagonists and extensive structural analysis reveal the open conformation of the receptor and the structural basis of TLR7 antagonism. One of the compounds shows efficacy in treating mouse model of systemic lupus erythematosus.

    • Shingo Tojo
    • Zhikuan Zhang
    • Toshiyuki Shimizu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Takuo Minato and colleagues determine the crystal and cryo-EM structures of the native C-phycocyanin (CPC) from the thermophilic cyanobacterium, Thermoleptolyngbya sp. O77, which was found to adopt both a conventional hexameric structure and a novel octameric assembly. These findings provide new insights into the assembly of CPCs and their mechanism of energy transfer.

    • Takuo Minato
    • Takamasa Teramoto
    • Ki-Seok Yoon
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10