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Showing 1–2 of 2 results
Advanced filters: Author: Natalia Arenas-Ramirez Clear advanced filters

  • IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a CD122-biased fusion protein that prevents binding of IL-2 to CD25 and promotes anti-tumor immune response in several preclinical metastatic cancer models.

    • Dilara Sahin
    • Natalia Arenas-Ramirez
    • Onur Boyman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The epigenetic modifier EZH2 is highly expressed in melanoma but its role in cancer initiation and progression is still unclear. Here the authors use mouse models and human cell lines to show that EZH2 has an essential role in melanoma progression and metastasis, thus highlighting its potential as a therapeutic target.

    • Daniel Zingg
    • Julien Debbache
    • Lukas Sommer
    Research
    Nature Communications
    Volume: 6, P: 1-17