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Cellular & Molecular Immunology (1)
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Advanced filters: Author: Natalia R. Mantuano Clear advanced filters

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

Targeted protein degradation of cell-surface glycoproteins suppresses cancer in mice.

Kayvon Pedram
D. Judy Shon
Carolyn R. Bertozzi
ResearchOpen Access03 Aug 2023
Nature Biotechnology

Volume: 42, P: 597-607
Targeted glycan degradation potentiates the anticancer immune response in vivo

An αHER2 antibody–neuraminidase conjugate, which selectively targets the removal of sialic acids from glycans on breast cancer cells, bypasses a glycoimmune checkpoint and enhances tumor cell killing by the host immune system.

Melissa A. Gray
Michal A. Stanczak
Carolyn R. Bertozzi
Research17 Aug 2020
Nature Chemical Biology

Volume: 16, P: 1376-1384
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2

Ronja Wieboldt
Michael Sandholzer
Natalia Rodrigues Mantuano
ResearchOpen Access06 Mar 2024
Cellular & Molecular Immunology

Volume: 21, P: 495-509
CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection

Frederico Alisson-Silva
Natália Rodrigues Mantuano
Adriane R. Todeschini
ResearchOpen Access13 Jun 2019
Scientific Reports

Volume: 9, P: 1-11