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Showing 1–2 of 2 results
Advanced filters: Author: Natalie Charitakis Clear advanced filters

  • Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

    • Mark W. Pocock
    • Janice D. Reid
    • James E. Hudson
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 821-840

  • McNamara et al. show that ALPK3 is an M-band protein required for phosphorylation of sarcomeric proteins and components of the protein quality control apparatus. Further, the autophagy receptor sequestosome-1 requires ALPK3 activity for sarcomeric localization.

    • James W. McNamara
    • Benjamin L. Parker
    • David A. Elliott
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 159-173