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Showing 1–4 of 4 results
Advanced filters: Author: Natalie M. Doig Clear advanced filters

  • GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.

    • Bradley M. Roberts
    • Natalie M. Doig
    • Stephanie J. Cragg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient to reduce cognitive flexibility.

    • Polina Kosillo
    • Natalie M. Doig
    • Helen S. Bateup
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • Mutations in LSM11 and RNU7-1, which encode components of the replication-dependent histone pre-mRNA–processing complex, cause an autoinflammatory syndrome due to enhanced interferon signaling mediated by the cGAS–STING pathway, showing an essential role for nuclear histones in suppressing the immunogenicity of self-DNA.

    • Carolina Uggenti
    • Alice Lepelley
    • Yanick J. Crow
    Research
    Nature Genetics
    Volume: 52, P: 1364-1372