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Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers

The paralogs cytidine diphosphate diacylglycerol synthase 1 and 2 form a potentially targetable synthetic lethal relationship in mesenchymal-like cancers that involves disruption of lipid metabolism.

Tim Arnoldus
Alex van Vliet
Daniel S. Peeper
ResearchOpen Access04 Jul 2025
Nature Genetics

Volume: 57, P: 1659-1671
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

In a mouse model of mammary carcinoma, loss of deleted in colorectal cancer (DCC) promotes metastasis formation, and in cell cultures derived from p53-deficient mouse mammary tumours DCC expression controls netrin-1-dependent cell survival, supporting the function of DCC as a context-dependent tumour suppressor that limits survival of disseminated tumour cells.

Paul Krimpenfort
Ji-Ying Song
Anton Berns
Research22 Feb 2012
Nature

Volume: 482, P: 538-541
The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage.

Laura Bornes
Lennart J. van Winden
Jacco van Rheenen
ResearchOpen Access04 Dec 2024
Nature

Volume: 637, P: 195-204
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Truncation of exon 18 of FGFR2 (FGFR2^ΔE18) is a potent driver mutation in mice and humans, and FGFR-targeted therapy should be considered for patients with cancer expressing stable FGFR2^ΔE18 variants.

Daniel Zingg
Jinhyuk Bhin
Jos Jonkers
ResearchOpen Access10 Aug 2022
Nature

Volume: 608, P: 609-617
Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Daniel Zingg
Jinhyuk Bhin
Jos Jonkers
Amendments and CorrectionsOpen Access01 Sept 2022
Nature

Volume: 609, P: E13
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research.

Oded Kopper
Chris J. de Witte
Hans Clevers
Research22 Apr 2019
Nature Medicine

Volume: 25, P: 838-849
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Els Wauters
Pierre Van Mol
Diether Lambrechts
ResearchOpen Access21 Jan 2021
Cell Research

Volume: 31, P: 272-290

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Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

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Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Search

Quick links