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Showing 1–6 of 6 results
Advanced filters: Author: Natalie Trevaskis Clear advanced filters

  • Increased delivery to immune cells in the cortex and paracortex of the lymph node can be achieved by conjugating cargo to nanoparticles via linkers that release at programmable rates.

    • Christopher J. H. Porter
    • Natalie L. Trevaskis
    News & Views
    Nature Nanotechnology
    Volume: 15, P: 423-425

  • Targeted delivery to the lymphatic system has the potential to improve bioavailability, enhance prophylactic and therapeutic vaccination or tolerance induction, and target drug delivery to lymph-resident infection or metastasis. In this Review, Trevaskis, Kaminskas and Porter provide an overview of lymphatic targeting and delivery strategies in drug development, and discuss the clinical applications of these approaches.

    • Natalie L. Trevaskis
    • Lisa M. Kaminskas
    • Christopher J. H. Porter
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 781-803

  • Visceral adipose tissue contains populations of regulatory T cells that exhibit sexual dimorphism, determined by the surrounding niche, and differ between male and female mice in terms of cell number, phenotype, transcriptional landscape and chromatin accessibility.

    • Ajithkumar Vasanthakumar
    • David Chisanga
    • Axel Kallies
    Research
    Nature
    Volume: 579, P: 581-585

  • Lipophilic, poorly water-soluble drug candidates are common outcomes of drug discovery programmes. Porter and colleagues discuss mechanisms by which lipids and lipidic excipients can improve oral absorption of lipophilic drugs, and provide a perspective on the future applications of lipid-based delivery systems.

    • Christopher J. H. Porter
    • Natalie L. Trevaskis
    • William N. Charman
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 231-248