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Showing 1–3 of 3 results
Advanced filters: Author: Natascha Roehlen Clear advanced filters

  • A comparison of the repertoire of SARS-CoV-2-specific epitopes targeted by T cells induced by vaccination or natural infection reveals that T cells predominantly target non-spike epitopes in convalescent individuals, while there is a broader spike-specific CD8+ T-cell response in vaccinees. Despite differences in T-cell response, the targeted T-cell epitopes were conserved between the wild-type and Omicron variants in both groups.

    • Julia Lang-Meli
    • Hendrik Luxenburger
    • Christoph Neumann-Haefelin
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 675-679

  • Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 memory T cell pool, thereby permitting reactivation of spike-specific CD8 + T cells upon breakthrough infection or 4th vaccination.

    • Matthias Reinscheid
    • Hendrik Luxenburger
    • Maike Hofmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.

    • Emilie Crouchet
    • Simonetta Bandiera
    • Thomas F. Baumert
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19