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Showing 1–5 of 5 results
Advanced filters: Author: Natasha Edman Clear advanced filters

  • The lysine methyltransferase SMYD5 and its newly identified substrate ribosomal protein L40 are implicated in the progression of gastric adenocarcinoma, and ablation of SMYD5 prevents metastatic disease in mouse models of this cancer.

    • Juhyung Park
    • Jibo Wu
    • Pawel K. Mazur
    Research
    Nature
    Volume: 632, P: 656-663

  • Immune receptors regulate immune responses and are key cancer immunotherapy targets. Here, the authors designed helical concave scaffolds to bind convex sites in immune receptors, creating high-affinity protein binders for TGFβRII, CTLA-4, and PD-L1. Co-crystal structures confirmed their therapeutic potential.

    • Wei Yang
    • Derrick R. Hicks
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Semisynthetic constructs of protein kinase CK2 incorporating nonhydrolyzable post-translational modifications now demonstrate the interplay between phosphorylation and glycosylation in regulating CK2 stability, controlling substrate specificity and modifying interactions with regulatory proteins.

    • Mary Katherine Tarrant
    • Hee-Sool Rho
    • Philip A Cole
    Research
    Nature Chemical Biology
    Volume: 8, P: 262-269

  • De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle proteins as building blocks, and provide an in-depth structural characterization of the resulting assemblies.

    • Yang Hsia
    • Rubul Mout
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The process of protein crystallization is poorly understood and difficult to program through the primary sequence. Here the authors develop a computational approach to designing three-dimensional protein crystals with prespecified lattice architectures with high accuracy.

    • Zhe Li
    • Shunzhi Wang
    • David Baker
    Research
    Nature Materials
    Volume: 22, P: 1556-1563