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A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

A human anti-IL-2 antibody that selectively expands regulatory T cells is developed in this study for clinical applications aiming to mitigate autoimmune and inflammatory disorders and to promote transplant tolerance.

Eleonora Trotta
Paul H. Bessette
Jeffrey A. Bluestone
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 1005-1014
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Colonic patches and isolated lymphoid follicles are lymphoid tissues that exist in the intestine. Ouyang and colleagues show that interleukin 22 maintains these structures and contributes to gut immune defenses during infection.

Naruhisa Ota
Kit Wong
Wenjun Ouyang
Research28 Aug 2011
Nature Immunology

Volume: 12, P: 941-948
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Mice have lineage-negative IL-7Rα⁺ (innate lymphoid) cells that contribute to type 2 immunity. Spits and colleagues identify a similar CRTH2⁺CD161⁺ population in human lungs and gut that produces IL-13 after stimulation.

Jenny M Mjösberg
Sara Trifari
Hergen Spits
Research11 Sept 2011
Nature Immunology

Volume: 12, P: 1055-1062
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T_H-17, T_H1 and T_H2 cells

Helper T cells become polarized to effect a 'division of labor'. Sallusto and Spits and colleagues identify a new subset of skin-homing helper T cells, T_H-22 cells, that secrete interleukin 22.

Sara Trifari
Charles D Kaplan
Hergen Spits
Research05 Jul 2009
Nature Immunology

Volume: 10, P: 864-871
Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC⁺ CD127⁺ natural killer–like cells

Mouse lymphoid tissue–inducer (LTi) cells require the transcription factor RORγt. Cupedo's group identifies RORγt⁺ human LTi cell equivalents as committed natural killer cell precursors, and teams led by Vivier and Diefenbach describe RORγt-expressing interleukin 22–producing natural killer cells in mouse gut.

Tom Cupedo
Natasha K Crellin
Hergen Spits
Research23 Nov 2008
Nature Immunology

Volume: 10, P: 66-74

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A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T_H-17, T_H1 and T_H2 cells

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC⁺ CD127⁺ natural killer–like cells

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A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

Search

Quick links

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T_H-17, T_H1 and T_H2 cells

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC⁺ CD127⁺ natural killer–like cells