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Showing 1–3 of 3 results
Advanced filters: Author: Nathalie Barilone Clear advanced filters

  • The α7 nicotinic receptor mediates neuronal communication in the brain. Here, the authors present cryo-EM structures of α7 in complex with single-chain antibodies, revealing an original mechanism of potentiation useful for the design of pro-cognitive drugs.

    • Marie S. Prevost
    • Nathalie Barilone
    • Pierre-Jean Corringer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • PimA provides an unusual example of conformational flexibility: structural, biophysical and disulfide trapping experiments now show a glycosyltransferase involved in tuberculosis virulence undergoes a major rearrangement upon contact with membranes.

    • David Giganti
    • David Albesa-Jové
    • Pedro M Alzari
    Research
    Nature Chemical Biology
    Volume: 11, P: 16-18

  • GABAA receptors mediate most inhibitory synaptic transmission in the brain. Here authors used concatemeric α1β2γ2 GABAA receptors to introduce gain-of-desensitization mutations one subunit at a time, revealing non-concerted rearrangements with a key contribution of the γ2 subunit during desensitization.

    • Marc Gielen
    • Nathalie Barilone
    • Pierre-Jean Corringer
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14