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Showing 1–2 of 2 results
Advanced filters: Author: Nathalie Bleimling Clear advanced filters

  • Rep15 is an effector that interacts with the GTPase Rab15. Here, the authors show that Rep15 also interacts with Rab3 paralogs and Rab34, present crystal structures of Rep15:Rab complexes and find that Rep15 depletion in glioblastoma cells decreases proliferation and mobility.

    • Amrita Rai
    • Anurag K. Singh
    • Roger S. Goody
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the bMERB and CH domain of EHBP1 form an intramolecular complex which auto-inhibits actin binding.

    • Amrita Rai
    • Nathalie Bleimling
    • Roger S. Goody
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16