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Advanced filters: Author: Nathan I Cherny Clear advanced filters

  • In this Perspective, Nathan Cherny appraises the FDA approvals of therapeutic agents granted for use in adult patients with solid tumours during the 5 years 2017–2021 against the aspirations of the Cancer Moonshot, in terms of sheer number of approvals, the strength of the supporting evidence and the magnitude of clinical benefit. He also outlines areas where improvements are needed to more confidently ensure that the clinical benefits of approved treatments justify the associated risks.

    • Nathan I. Cherny
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 19, P: 486-492

  • Sedation is used in multiple settings in palliative care, such as transient controlled sedation, respite sedation, and sedation for refractory psychological or existential suffering; however, it is a controversial technique that can diminish the capacity of the patient to interact, function, and, in some cases, to live. Cherny provides a comprehensive account of the risks associated with different sedation approaches and also highlights the controversies and ethical considerations for palliative care medicine.

    • Nathan I Cherny
    Reviews
    Nature Clinical Practice Oncology
    Volume: 3, P: 492-500