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Showing 1–10 of 10 results
Advanced filters: Author: Nathaniel A. Wesley Clear advanced filters
  • Spangler et al. used a substrate inhibitor covalent conjugate strategy to solve cryo-EM structures of nucleosomes in complex with the lysine demethylase KDM2, which demonstrates that KDM2A, but not its closely related paralog, KDM2B, anchors to the acidic patch to direct histone H3K36-specific demethylation.

    • Cathy J. Spangler
    • Aleksandra Skrajna
    • Robert K. McGinty
    Research
    Nature Chemical Biology
    Volume: 19, P: 624-632
  • Sensory nervous systems adapt to their environment—a mechanism thought to ensure network dynamics remain critical. Visual cortex experiments show that adaptation maintains criticality even as sensory input drives the system away from this regime.

    • Woodrow L. Shew
    • Wesley P. Clawson
    • Ralf Wessel
    Research
    Nature Physics
    Volume: 11, P: 659-663
  • Cryo-EM structures of human ESCRT-III proteins forming membrane-bound and membrane-free filaments show how CHMP1B and IST1 polymerize sequentially, driving membrane tubulation, constriction and bilayer thinning, leading to membrane fission.

    • Henry C. Nguyen
    • Nathaniel Talledge
    • Adam Frost
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 392-399
  • Upon the binding of small ligands, nuclear receptors regulate the transcription of genes that are associated with a number of disease mechanisms. Here, the authors report on a novel allosteric ligand binding site on the nuclear receptor RORγt.

    • Marcel Scheepstra
    • Seppe Leysen
    • Luc Brunsveld
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10
  • Next-generation skin-inspired electronics require enhanced mechanical robustness and device complexity including elasticity, solvent resistance, and facile patternability. Here, the authors show a molecular design concept that simultaneously achieves all these requirements by covalently linking an in-situ formed rubber matrix with polymer electronic materials.

    • Yu Zheng
    • Zhiao Yu
    • Zhenan Bao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11
  • Cataloging microbial genomes from Earth’s environments expands the known phylogenetic diversity of bacteria and archaea.

    • Stephen Nayfach
    • Simon Roux
    • Emiley A. Eloe-Fadrosh
    ResearchOpen Access
    Nature Biotechnology
    Volume: 39, P: 499-509