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Advanced filters: Author: Nathaniel F. Henneman Clear advanced filters

Lysosomal phosphoinositide turnover acts upstream of RagGTPase–mTORC1 and controls muscle growth

The accumulation of phosphoinositides at the lysosomal surface is shown to enhance RagGTPase–mTORC1 activity, which affects skeletal muscle cell differentiation. Inhibition of this signalling pathway improves muscle physiology in a mouse myopathy model.

Melanie Picot
Nesrine Hifdi
Karim Hnia
ResearchOpen Access18 Mar 2026
Nature Metabolism

Volume: 8, P: 624-645
Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis

Alkhoury et al. show that the class 3 phosphatidylinositol-3-kinase Vps15 subunit coactivates the circadian clock transcription factor Bmal1–Clock for metabolic rhythmicity in the liver and promotes pro-anabolic de novo purine synthesis.

Chantal Alkhoury
Nathaniel F. Henneman
Ganna Panasyuk
ResearchOpen Access06 Jul 2023
Nature Cell Biology

Volume: 25, P: 975-988

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Lysosomal phosphoinositide turnover acts upstream of RagGTPase–mTORC1 and controls muscle growth

Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis

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