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Showing 1–3 of 3 results
Advanced filters: Author: Nathaniel H. Sherden Clear advanced filters

  • Iridoids are a large family of bicyclic natural products that possess anticancer, anti-inflammatory, antifungal and antibacterial activities; here the essential cyclization step in their biosynthesis is identified, opening up the possibility of production of naturally occurring and synthetic variants of iridoids for use in pharmacy or agriculture.

    • Fernando Geu-Flores
    • Nathaniel H. Sherden
    • Sarah E. O’Connor
    Research
    Nature
    Volume: 492, P: 138-142

  • The biosynthesis of iridoids, a class of bicyclic monoterpenes, features an atypical cyclization reaction catalyzed by iridoid synthase (ISY). Crystallographic and biochemical characterization of ISY from Catharanthus roseus provides insights into the ISY enzymatic mechanism and highlights similarities with the homologous progesterone 5β-reductase.

    • Hajo Kries
    • Lorenzo Caputi
    • Sarah E O'Connor
    Research
    Nature Chemical Biology
    Volume: 12, P: 6-8