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Showing 1–6 of 6 results
Advanced filters: Author: Nathaniel J. Traaseth Clear advanced filters

  • Efflux pumps confer antibiotic resistance by coupling proton import with drug export. In this work, the authors uncover the proton-coupled transport mechanism for the clinically relevant efflux pump NorA from the pathogenic bacterium S. aureus.

    • Jianping Li
    • Yan Li
    • Nathaniel J. Traaseth
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Here, the authors reveal the protonation of a single membrane embedded glutamate residue within the homodimer of the efflux transporter EmrE modulates the structure and dynamics in an allosteric manner using NMR spectroscopy.

    • Jianping Li
    • Ampon Sae Her
    • Nathaniel J. Traaseth
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • X-ray crystallography, solution NMR and biochemical and cell-based analyses reveal a model where catalytically repressed receptor tyrosine kinases accomplish activation loop (A-loop) tyrosine transphosphorylation.

    • Lingfeng Chen
    • William M. Marsiglia
    • Moosa Mohammadi
    Research
    Nature Chemical Biology
    Volume: 16, P: 267-277

  • Cryo-EM analysis of the quinolone transporter NorA in complex with synthetic antigen-binding fragments (Fabs) inspired peptide mimics of the Fabs that inhibit methicillin-resistant Staphylococcus aureus in combination with the antibiotic norfloxacin.

    • Douglas N. Brawley
    • David B. Sauer
    • Nathaniel J. Traaseth
    Research
    Nature Chemical Biology
    Volume: 18, P: 706-712