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Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice

Navneet A. Vasistha
Mandy Johnstone
Siddharthan Chandran
Research23 Oct 2019
Molecular Psychiatry

Volume: 24, P: 1567
Author Correction: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Ulrich Pfisterer
Viktor Petukhov
Konstantin Khodosevich
Amendments and CorrectionsOpen Access19 Nov 2020
Nature Communications

Volume: 11, P: 1
Hanging by the tail: progenitor populations proliferate

A study now identifies a new progenitor subtype in the developing mouse cortex, similar to the outer radial glia progenitors described previously in human, ferret and other mammals with larger, folded brains.

Zoltán Molnár
Navneet A Vasistha
Fernando Garcia-Moreno
News & Views26 Apr 2011
Nature Neuroscience

Volume: 14, P: 538-540
Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.

Ulrich Pfisterer
Viktor Petukhov
Konstantin Khodosevich
ResearchOpen Access07 Oct 2020
Nature Communications

Volume: 11, P: 1-19
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca²⁺-permeable AMPA receptor-mediated excitotoxicity

Repeat expansion mutation in C9ORF72 is the most common cause of familial ALS. Here, the authors generate motor neurons from cells of patients with C9ORF72 mutations, and characterize changes in gene expression in these motor neurons compared to genetically corrected lines, which suggest that glutamate receptor subunit GluA1 is dysregulated in this form of ALS.

Bhuvaneish T. Selvaraj
Matthew R. Livesey
Siddharthan Chandran
ResearchOpen Access24 Jan 2018
Nature Communications

Volume: 9, P: 1-14
Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Navneet A. Vasistha
Maria Pardo-Navarro
Konstantin Khodosevich
ResearchOpen Access08 Oct 2019
Molecular Psychiatry

Volume: 25, P: 2313-2329
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction

Navneet A. Vasistha
Mandy Johnstone
Siddharthan Chandran
ResearchOpen Access03 Sept 2019
Molecular Psychiatry

Volume: 24, P: 1641-1654
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Mandy Johnstone
Navneet A. Vasistha
Siddharthan Chandran
ResearchOpen Access06 Nov 2018
Molecular Psychiatry

Volume: 24, P: 294-311

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Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice

Author Correction: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Hanging by the tail: progenitor populations proliferate

Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca²⁺-permeable AMPA receptor-mediated excitotoxicity

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

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