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Showing 1–4 of 4 results
Advanced filters: Author: Neil Cobelli Clear advanced filters

  • Periprosthetic osteolysis is a common reason for failure or revision of joint replacement surgery, and is a result of the inflammatory reaction to debris particles generated by wearing of the implant over time. In this Review, the authors describe the cellular and molecular mediators of this process and how it might be prevented or treated.

    • Neil Cobelli
    • Brian Scharf
    • Laura Santambrogio
    Reviews
    Nature Reviews Rheumatology
    Volume: 7, P: 600-608

  • Endosomes contain hydrolytic enzymes, and recent reports have suggested that the endosomal membrane can be damaged by wear particles, resulting in the release of their contents and an inflammatory response. In this study, a role for annexin II in the repair of the damaged endosome membrane is reported.

    • Brian Scharf
    • Cristina C. Clement
    • Laura Santambrogio
    Research
    Nature Communications
    Volume: 3, P: 1-10

  • Conditions such as diabetes, metabolic syndrome and chronic inflammation can induce extensive post-translational modifications in cartilage structural proteins, with consequences for the molecular structure and, ultimately, the function of cartilage. This article reviews the biochemical changes to articular cartilage matrix proteins driven by metabolic and oxidative stress as well as their relationship with cartilage degeneration.

    • John A. Hardin
    • Neil Cobelli
    • Laura Santambrogio
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 521-529