Heterotopic ossification (HO) is the pathological formation of bone in soft tissues involving hydroxyapatite (HA) formation in vivo, however, the exact mechanism of HA formation remains debated. Here, the authors demonstrate the chemical mapping of human HO and the transformation of amorphous calcium carbonate in physiological conditions and reveal the role of ATP in bone mineralisation.
- Cong Sui
- Thomas E. Robinson
- Liam M. Grover