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Showing 1–8 of 8 results
Advanced filters: Author: Neil J. Ganem Clear advanced filters

  • Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma formation.

    • Marc A. Vittoria
    • Nathan Kingston
    • Neil J. Ganem
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Hippo pathway inactivation plays a role in many cancers, although how tumor cells depress signaling is unclear. Here, Lim et al. identify STK25, which activates LATS in a manner distinct from other upstream kinases and is focally deleted from a range of human cancers.

    • Sanghee Lim
    • Nicole Hermance
    • Neil J. Ganem
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Chromosomes within micronuclei are shown to be damaged during S phase and become highly fragmented, and the damaged pieces can be reincorporated into the genome.

    • Karen Crasta
    • Neil J. Ganem
    • David Pellman
    Research
    Nature
    Volume: 482, P: 53-58

  • Whole-genome doubling (WGD) commonly occurs in many solid tumors. Here the authors use a zebrafish model of melanoma and in vitro models to show that BRAFV600E induces WGD via inhibition of RhoA and cytokinesis failure.

    • Revati Darp
    • Marc A. Vittoria
    • Craig J. Ceol
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Cancer cells that have undergone whole-genome doubling are more reliant than their near-diploid counterparts on DNA-replication factors, the spindle-assembly checkpoint and a mitotic kinesin protein, KIF18A.

    • Ryan J. Quinton
    • Amanda DiDomizio
    • Neil J. Ganem
    Research
    Nature
    Volume: 590, P: 492-497

  • Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the presence of extra centrosomes, but a direct mechanistic link between CIN and extra centrosomes has not been established. Live-cell imaging is now used to demonstrate that extra centrosomes can promote chromosome missegregation as a consequence of cells passing through a transient 'multipolar spindle intermediate'.

    • Neil J. Ganem
    • Susana A. Godinho
    • David Pellman
    Research
    Nature
    Volume: 460, P: 278-282