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Showing 1–3 of 3 results
Advanced filters: Author: Neil J. Rzechorzek Clear advanced filters

  • Thermophilic archaea have a minimal double-strand DNA break repair apparatus consisting of the HerA ATPase, NurA nuclease and Mre11–Rad50 complex. Here the authors solve the structure of a hexameric HerA ring from Sulfolobus solfataricus, and provide insight into a novel mechanism of DNA repair.

    • Neil J. Rzechorzek
    • John K. Blackwood
    • Nicholas P. Robinson
    Research
    Nature Communications
    Volume: 5, P: 1-15

  • Inactivation of DNPH1 leads to hmdU incorporation into DNA, sensitising BRCA-deficient cells to PARP inhibitors. Crystal structures of DNPH1 bound to hmdU monophosphate reveal a two-step mechanism for hydrolysis via a glycosyl-enzyme intermediate.

    • Neil J. Rzechorzek
    • Simone Kunzelmann
    • Stephen C. West
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • CtIP helps maintain genomic stability by promoting DNA double-strand-break repair. Structural and biophysical analyses now show that the N terminus of human CtIP forms a tetrameric structure that is required for resection of broken DNA ends to permit their repair by homologous recombination.

    • Owen R Davies
    • Josep V Forment
    • Luca Pellegrini
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 150-157