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Showing 1–4 of 4 results
Advanced filters: Author: Neil Lineberry Clear advanced filters

  • Deubiquitinating enzymes remove polyubiquitin chains from and alter the fate of specific target proteins. The CYLD deubiquitinating enzyme regulates proximal T cell receptor signaling in thymocytes by selectively binding to and deubiquitinating the active form of the kinase Lck.

    • Neil Lineberry
    • C Garrison Fathman
    News & Views
    Nature Immunology
    Volume: 7, P: 369-370

  • Understanding the state of long-lived functional unresponsiveness of T cells, known as T-cell anergy, could help to prevent T-cell-driven autoimmune diseases. This Review discusses the molecular mechanisms underlying this phenomenon and, in particular, the role of E3 ubiquitin ligases.

    • C. Garrison Fathman
    • Neil B. Lineberry
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 599-609

  • Caspases are intracellular proteases and key initiators and effectors of apoptosis. Here the authors describe fluorescently labeled activity-based probes that allow the noninvasive in vivo monitoring of the kinetics of caspase activity. Approaches to optimize the probes to enhance their specificity and increase uptake into apoptotic cells are outlined, and their use in tracking the early stages of apoptosis in two mouse models (dexamethasone and the monoclonal antibody Apomab) is demonstrated.

    • Laura E Edgington
    • Alicia B Berger
    • Matthew Bogyo
    Research
    Nature Medicine
    Volume: 15, P: 967-973