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Showing 1–4 of 4 results
Advanced filters: Author: Nele Hug Clear advanced filters

  • UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold in promoting UPF1 phosphorylation by SMG1 to promotes NMD.

    • Roberto Melero
    • Nele Hug
    • Oscar Llorca
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.

    • Noemi Fernandez
    • Ross A. Cordiner
    • Javier F. Cáceres
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12